Article

Neuronal STING drives neuroimmune circuits underlying atopic itch

2025-11-28

Abstract excerpt

<h4>Background: </h4> Chronic itch is a hallmark symptom of atopic dermatitis (AD), but the molecular mechanisms within sensory neurons that underlie itch are still not fully understood. <h4>Methods: </h4>: Transcriptomic profiling of dorsal root ganglia (DRG) from an AD-like mouse model with graded disease severity and scratching behavior was used to identify itch-associated molecules in sensory neurons. Pharmac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68273a6b-4d21-593e-b305-5e5900cc481b
DOI: 10.22541/au.176432425.50521984/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neuronal STING drives neuroimmune circuits underlying atopic itchDOI 10.22541/au.176432425.50521984/v1Read

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce ItchSemantic proximity Read

Molecular signature of pruriceptive MrgprA3 <sup>+</sup> neuronsSemantic proximity Read

A basophil-neuronal axis promotes itch.Semantic proximity Read

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug developmentSemantic proximity Read

Presynaptic inhibition of cutaneous afferents prevents self-generated itchSemantic proximity Read

Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in PsoriasisSemantic proximity Read

Direct sensitizing and activating effects of interleukin 31 are restricted to a single, functionally and transcriptionally classified porcine DRG neuron subtypeSemantic proximity Read

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activationSemantic proximity Read

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitisSemantic proximity Read

Decoding the neuroimmune axis in the atopic march: mechanisms and implicationsSemantic proximity Read

Water Extract of Senecio scandens Buch.-Ham. Ameliorates Allergic Contact Dermatitis by Targeting MrgprB2 and Restoring Sustained Potassium Currents in Dorsal Root Ganglion NeuronsSemantic proximity Read

NGN2 Expression and Regional Patterning Allow Rapid Differentiation from hiPSCs to DRG-Like Neurons Responsive to Type 2 CytokinesSemantic proximity Read