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Article

Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis

30 Aug 2023

Abstract excerpt

Mast cells (MCs) contribute to skin inflammation. In psoriasis, the activation of cutaneous neuroimmune networks commonly leads to itch. To dissect the unique contribution of MCs to the cutaneous neuroinflammatory response in psoriasis, we examined their density, distribution, relation to nerve fibres and disease severity, and molecular signature by comparing RNA-seq analysis of MCs isolated from the skin of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37681909
DOI: 10.3390/cells12172177

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