Article
A basophil-neuronal axis promotes itch.
Cell - 21 Jan 2021
Wang Fang, Trier Anna M, Li Fengxian, Kim Seonyoung, Chen Zhen, Chai Jiani N, Mack Madison R, Morrison Stephanie A, Hamilton Jennifer D, Baek Jinok, Yang Ting-Lin B, Ver Heul Aaron M, Xu Amy Z, Xie Zili, Dong Xintong, Kubo Masato, Hu Hongzhen, Hsieh Chyi-Song, Dong Xinzhong, Liu Qin, Margolis David J, Ardeleanu Marius, Miller Mark J, Kim Brian S
Abstract excerpt
Itch is an evolutionarily conserved sensation that facilitates expulsion of pathogens and noxious stimuli from the skin. However, in organ failure, cancer, and chronic inflammatory disorders such as atopic dermatitis (AD), itch becomes chronic, intractable, and debilitating. In addition to chronic itch, patients often experience intense acute itch exacerbations. Recent discoveries have unearthed the neuroimmune...
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