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Article

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development

7 Sept 2021

Abstract excerpt

Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin diseases in the world. It is characterized by recurrent eczematous lesions and intense itch, and many cytokines are involved in the pathogenesis of AD. Among them, much attention has been paid to interleukin 31 (IL-31) as an AD-associated itch mediator. IL-31 is mainly produced by CD4+ helper T cells and transmits the signals via a...

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PMID: 34491348
DOI: 10.1093/intimm/dxab065

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