Article
Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis.
Nature - 1 Oct 2024
Takaoka Minoru, Zhao Xiaohui, Lim Hwee Ying, Magnussen Costan G, Ang Owen, Suffee Nadine, Schrank Patricia R, Ong Wei Siong, Tsiantoulas Dimitrios, Sommer Felix, Mohanta Sarajo K, Harrison James, Meng Yaxing, Laurans Ludivine, Wu Feitong, Lu Yuning, Masters Leanne, Newland Stephen A, Denti Laura, Hong Mingyang, Chajadine Mouna, Juonala Markus, Koskinen Juhani S, Kähönen Mika, Pahkala Katja, Rovio Suvi P, Mykkänen Juha, Thomson Russell, Kaisho Tsuneyasu, Habenicht Andreas J R, Clement Marc, Tedgui Alain, Ait-Oufella Hafid, Zhao Tian X, Nus Meritxell, Ruhrberg Christiana, Taleb Soraya, Williams Jesse W, Raitakari Olli T, Angeli Véronique, Mallat Ziad
Abstract excerpt
Hyperlipidaemia is a major risk factor of atherosclerotic cardiovascular disease (ASCVD). Risk of cardiovascular events depends on cumulative lifetime exposure to low-density lipoprotein cholesterol (LDL-C) and, independently, on the time course of exposure to LDL-C, with early exposure being associated with a higher risk1. Furthermore, LDL-C fluctuations are associated with ASCVD outcomes2-4. However, the...
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