Article
Mutations in SORL1 and MTHFDL1 possibly contribute to the development of Alzheimer's disease in a multigenerational Colombian Family.
PloS one - 1 Jan 2022
Tejada Moreno Johanna Alexandra, Villegas Lanau Andrés, Madrigal Zapata Lucia, Baena Pineda Ana Yulied, Velez Hernandez Juan, Campo Nieto Omer, Soto Ospina Alejandro, Araque Marín Pedronel, Rishishwar Lavanya, Norris Emily T, Chande Aroon T, Jordan I King, Bedoya Berrio Gabriel
Abstract excerpt
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, affecting over 50 million people worldwide in 2020 and this number will triple to 152 million by 2050. Much of the increase will be in developing countries like Colombia. In familial forms, highly penetrant mutations have been identified in three genes, APP, PSEN1, and PSEN2, supporting a role for amyloid-β peptide. In sporadic forms,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.