Article

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations

2022-08-26

Abstract excerpt

<title>Abstract</title> <p>The SARS-CoV-2 main protease (Mpro) is a major therapeutic target. The Mpro inhibitor, nirmatrelvir, is the antiviral component of Paxlovid, an orally available treatment for COVID-19. As Mpro inhibitor use increases, drug resistant mutations will likely emerge. We have established a non-pathogenic system, in which yeast growth serves as a proxy for Mpro activity, enabling rapid identif...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9f2db530-7e45-517f-8f12-315d9bd44ba9
DOI: 10.21203/rs.3.rs-1942964/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutationsDOI 10.21203/rs.3.rs-1942964/v1Read

A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations.Semantic proximity Read

A yeast-based system to study SARS-CoV-2 M <sup>pro</sup> structure and to identify nirmatrelvir resistant mutationsSemantic proximity Read

Systematic analyses of the resistance potential of drugs targeting SARS-CoV-2 main proteaseSemantic proximity Read

Meisoindigo: An Effective Inhibitor of SARS-CoV-2 Main Protease Revealed by Yeast SystemSemantic proximity Read

Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvirSemantic proximity Read

Distal Protein-Protein Interactions Contribute to SARS-CoV-2 Main Protease Substrate Binding and Nirmatrelvir ResistanceSemantic proximity Read

Contributions of hyperactive mutations in M <sup>pro</sup> from SARS-CoV-2 to drug resistanceSemantic proximity Read

Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance.Semantic proximity Read

Comprehensive fitness landscape of SARS-CoV-2 M <sup>pro</sup> reveals insights into viral resistance mechanismsSemantic proximity Read

Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50.Semantic proximity Read

Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to NirmatrelvirSemantic proximity Read

The substitutions L50F, E166A and L167F in SARS-CoV-2 3CLpro are selected by a protease inhibitor <i>in vitro</i> and confer resistance to nirmatrelvirSemantic proximity Read