Article
Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors.
Behavior genetics - 1 Sept 2006
Stead John D H, Clinton Sarah, Neal Charles, Schneider Johanna, Jama Abas, Miller Sue, Vazquez Delia M, Watson Stanley J, Akil Huda
Abstract excerpt
Outbred Sprague-Dawley rats can be classified as high responders (HR) or low responders (LR) based on their levels of exploratory locomotion in a novel environment. While this novelty-seeking dimension was originally related to differential vulnerability to substance abuse, behavioral, neuroendocrine and gene expression studies suggest a fundamental difference in emotional reactivity between these animals. Here,...
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