Article
Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.
Biological psychiatry - 1 Nov 2011
Hettema John M, Webb Bradley T, Guo An-Yuan, Zhao Zhongming, Maher Brion S, Chen Xiangning, An Seon-Sook, Sun Cuie, Aggen Steven H, Kendler Kenneth S, Kuo Po-Hsiu, Otowa Takeshi, Flint Jonathan, van den Oord Edwin J
Abstract excerpt
BACKGROUND: Anxiety disorders are common psychiatric conditions that are highly comorbid with each other and related phenotypes such as depression, likely due to a shared genetic basis. Fear-related behaviors in mice have long been investigated as potential models of anxiety disorders, making integration of information from both murine and human genetic data a powerful strategy for identifying potential...
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