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Article

The role of amino acid sequence in the self-association of therapeutic monoclonal antibodies: insights from coarse-grained modeling.

The journal of physical chemistry. B - 7 Feb 2013

Chaudhri Anuj, Zarraga Isidro E, Yadav Sandeep, Patapoff Thomas W, Shire Steven J, Voth Gregory A

Abstract excerpt

Coarse-grained computational models of therapeutic monoclonal antibodies and their mutants can be used to understand the effect of domain-level charge-charge electrostatics on the self-association phenomena at high protein concentrations. The coarse-grained models are constructed for two antibodies at different coarse-grained resolutions by using six different concentrations. It is observed that a particular...

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Identifiers

PMID: 23316912
DOI: 10.1021/jp3108396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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