Article

Self-Interaction Nanoparticle Spectroscopy Predicts High-Concentration Viscosity of Therapeutic IgG1 Antibodies

2026-04-21

Abstract excerpt

Predicting high-concentration viscosity of monoclonal antibodies such as IgG1 is crucial for their development as therapeutics for subcutaneous delivery. Unfortunately, traditional experimental rheometry methods for assessing viscosity are low-throughput. This study evaluates Self-Interaction Nanoparticle Spectroscopy (SINS) assays—specifically charge-stabilized SINS (CS-SINS) and PEG-stabilized SINS (PS-SINS)—for...

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Literature Corpus work: ee4dca90-16aa-5451-adf6-61a6b0b05efe
DOI: 10.64898/2026.04.16.719068

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