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Article

Modulation of the high concentration viscosity of IgG1 antibodies using clinically validated Fc mutations.

mAbs - 1 Jan 2024

Heisler Joel, Kovner Daniel, Izadi Saeed, Zarzar Jonathan, Carter Paul J

Abstract excerpt

The self-association of therapeutic antibodies can result in elevated viscosity and create problems in manufacturing and formulation, as well as limit delivery by subcutaneous injection. The high concentration viscosity of some antibodies has been reduced by variable domain mutations or by the addition of formulation excipients. In contrast, the impact of Fc mutations on antibody viscosity has been minimally...

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Identifiers

PMID: 39028186
DOI: 10.1080/19420862.2024.2379560
PMCID: PMC11262234

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