Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode

doi:10.1038/s41467-020-19109-w

Article

Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode

20 Oct 2020

Abstract excerpt

Gonadotrophin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone, is the main regulator of the reproductive system, acting on gonadotropic cells by binding to the GnRH1 receptor (GnRH1R). The GnRH-GnRH1R system is a promising therapeutic target for maintaining reproductive function; to date, a number of ligands targeting GnRH1R for disease treatment are available on the market. Here, we...

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