Article

Zonal human hepatocytes are differentially permissive to <i>Plasmodium falciparum</i> malaria parasites

2020-06-29

Abstract excerpt

Plasmodium falciparum (Pf) is a major cause of malaria. The mosquito-borne parasite asymptomatically infects hepatocytes in the liver. The resulting schizonts undergo massive replication to generate blood-infective merozoites. Liver lobules are zonated: hepatocytes in different zones perform differential metabolic functions. In search for specific host conditions that affect infectability, we studied the Pf paras...

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Literature Corpus work: 67a29d0f-289d-5021-8303-48e48d63b7ee
DOI: 10.1101/2020.06.29.175968

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