Development of an Ectopic huLiver Model for <i>Plasmodium</i> Liver Stage Infection

Abstract excerpt

Early Plasmodium falciparum and P. vivax infection requires parasite replication within host hepatocytes, referred to as liver stage (LS). However, limited understanding of infection dynamics in human LS exists due to species-specificity challenges. Reported here is a reproducible, easy-to-manipulate, and moderate-cost in vivo model to study human Plasmodium LS in mice; the ectopic huLiver model. Ectopic huLive...

Topics

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• Aquaculture disease management and microbiota
• Drug-Induced Hepatotoxicity and Protection
• Drug Transport and Resistance Mechanisms
• Liver Disease and Transplantation
• Liver Disease Diagnosis and Treatment
• Malaria Research and Control
• Mosquito-borne diseases and control
• Parasites and Host Interactions

Identifiers and source

Literature Corpus work

6ba67c6f-8615-537e-a681-ab0a9cd9889c

DOI

10.1101/2022.12.01.518796