Article

A spatiotemporally resolved single cell atlas of the <i>Plasmodium</i> liver stage

2021-12-03

Abstract excerpt

Malaria infection involves an obligatory, yet clinically silent liver stage 1,2 . Hepatocytes operate in repeating units termed lobules, exhibiting heterogeneous gene expression patterns along the lobule axis 3 , but the effects of hepatocyte zonation on parasite development have not been molecularly explored. Here, we combine single-cell RNA sequencing 4 and single-molecule transcript imaging 5 to characteriz...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1ec6333-f02d-5dc8-b8e4-3e23f88454ce
DOI: 10.1101/2021.12.03.471111

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A spatiotemporally resolved single cell atlas of the <i>Plasmodium</i> liver stageDOI 10.1101/2021.12.03.471111Read

RNA-Seq Analysis Illuminates the Early Stages of <i>Plasmodium</i> Liver InfectionSemantic proximity Read

A single-cell liver atlas of Plasmodium vivax infectionSemantic proximity Read

RNA-Seq Analysis Illuminates the Early Stages of Plasmodium Liver InfectionSemantic proximity Read

Host-Pathogen Interactions in the <i>Plasmodium</i> -Infected Mouse Liver at Spatial and Single-Cell ResolutionSemantic proximity Read

Single-cell RNA profiling of <i>Plasmodium vivax</i> -infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targetsSemantic proximity Read

Single-cell RNA profiling of Plasmodium vivax-infected hepatocytes reveals parasite- and host- specific transcriptomic signatures and therapeutic targetsSemantic proximity Read

The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete <i>Plasmodium</i> life cycleSemantic proximity Read

Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing speciesSemantic proximity Read

A single-cell atlas of <i>Plasmodium falciparum</i> transmission through the mosquitoSemantic proximity Read

A single-cell atlas of Plasmodium falciparum transmission through the mosquitoSemantic proximity Read

Transcriptome and histone epigenome of <i>Plasmodium vivax</i> salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiationSemantic proximity Read

Gene signatures and host-parasite interactions revealed by dual single-cell profiling of <i>Plasmodium vivax</i> liver infectionSemantic proximity Read