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Development of Plasmodium falciparum liver-stages in hepatocytes derived from human fetal liver organoid cultures

2 Aug 2023

Abstract excerpt

Plasmodium falciparum (Pf) parasite development in liver represents the initial step of the life-cycle in the human host after a Pf-infected mosquito bite. While an attractive stage for life-cycle interruption, understanding of parasite-hepatocyte interaction is inadequate due to limitations of existing in vitro models. We explore the suitability of hepatocyte organoids (HepOrgs) for Pf-development and show that...

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PMID: 37532704
DOI: 10.1038/s41467-023-40298-7

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