Article

HLJ1 amplifies endotoxin–induced sepsis severity by promoting IL-12 heterodimerization in macrophages

2022-01-06

Abstract excerpt

Heat shock protein (HSP) 40 has emerged as a key actor in both innate and adaptive immunity, whereas the role of HLJ1, a molecular chaperone in HSP40 family, in modulating endotoxin–induced sepsis severity is still unclear. Here, we use single-cell RNA sequencing to characterize mouse liver nonparenchymal cell populations under LPS (lipopolysaccharide) stimulation, and show that HLJ1 deletion affected IFN-γ-relate...

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Literature Corpus work: 679765aa-44ea-57ed-a42e-68b4d3a89955
DOI: 10.1101/2022.01.05.475083

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