Article

ZBTB7B couples interferon response to mitophagy impairment and inflammasome activation in septic ARDS

2026-06-05

Abstract excerpt

<title>Abstract</title> <p> Sepsis-driven hyperinflammation causes acute respiratory distress syndrome (ARDS), yet immunotherapies targeting inflammation are limited by molecular heterogeneity. Transcriptomic analyses identify an interferon endotype strongly associated with systemic inflammation and organ damage, but the underlying mechanism remains unclear. Here, we identify ZBTB7B as a central regulator that c...

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Literature Corpus work: 87708d91-ac45-5573-82a8-47764375abfd
DOI: 10.21203/rs.3.rs-9906083/v1

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