Article

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

2021-03-25

Abstract excerpt

Signaling pathways that control vital features of leukemic stem cells including multipotency, self-renewal, clonal expansion and quiescence remain unclear. Emerging studies illustrate critical roles for lysosomes in hematopoietic and leukemic stem cell fate. By investigating consequences of INPP4B alterations in AML, we have discovered its role in driving leukemic ‘stemness’. We observed that INPP4B is highly ex...

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Literature Corpus work: 67950b8f-df91-5dbc-9b8e-2ac0968d286c
DOI: 10.1101/2021.03.25.437029

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