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Article

INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.

Journal of experimental & clinical cancer research : CR - 17 Jan 2018

Jin Hongjun, Yang Liyuan, Wang Lu, Yang Zailin, Zhan Qian, Tao Yao, Zou Qin, Tang Yuting, Xian Jingrong, Zhang Shuaishuai, Jing Yipei, Zhang Ling

Abstract excerpt

BACKGROUND: Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification. The genetic events underlying oncogenesis in NPM1-mutated AML that is characterized by a normal karyotype remain unclear. Inositol polyphosphate 4-phosphatase type II (INPP4B), a new factor in the phosphoinositide-3 kinase (PI3K)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29343273
DOI: 10.1186/s13046-018-0675-9
PMCID: PMC5773044

Genes

NPM1
SGK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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