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Article

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML.

Blood - 30 Apr 2015

Rijal Sewa, Fleming Shaun, Cummings Nik, Rynkiewicz Natalie K, Ooms Lisa M, Nguyen Nhu-Y N, Teh Tse-Chieh, Avery Sharon, McManus Julie F, Papenfuss Anthony T, McLean Catriona, Guthridge Mark A, Mitchell Christina A, Wei Andrew H

Abstract excerpt

Phosphoinositide signaling regulates diverse cellular functions. Phosphoinositide-3 kinase (PI3K) generates PtdIns(3,4,5)P3 and PtdIns(3,4)P2, leading to the activation of proliferative and anti-apoptotic signaling pathways. Termination of phosphoinositide signaling requires hydrolysis of inosito...

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Share to Drug Resistance, Neoplasm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Myeloid, Acute

Share to Phosphoric Monoester Hydrolases

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Source

Identifiers

PMID: 25736313
DOI: 10.1182/blood-2014-09-603555

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25736313-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML.PMID 25736313Read ↗

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Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progressionSemantic proximity Read ↗

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesisSemantic proximity Read ↗

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