Article
INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia.
Leukemia - 1 Jul 2015
Dzneladze I, He R, Woolley J F, Son M H, Sharobim M H, Greenberg S A, Gabra M, Langlois C, Rashid A, Hakem A, Ibrahimova N, Arruda A, Löwenberg B, Valk P J M, Minden M D, Salmena L
Abstract excerpt
In this study, we investigated the role of inositol polyphosphate-4-phosphatase, type-II (INPP4B) in acute myeloid leukemia (AML). We observed that AML patients with high levels of INPP4B (INPP4B(high)) had poor response to induction therapy, shorter event-free survival and shorter overall survival. Multivariate analyses demonstrated that INPP4B(high) was an independent predictor of poor prognosis, significantly...
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