Article

TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia

2021-08-24

Abstract excerpt

The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD). Because abnormalities in Ca 2+ signaling have been observed in several AD models, we investigated TREM2 regulation of Ca 2+ signaling in human induced pluripotent s...

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Literature Corpus work: 67868626-0878-58b2-9671-368f6df0d1d2
DOI: 10.1101/2021.08.24.457491

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