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Article

Multistep process of FUS aggregation in the cell cytoplasm involves RNA-dependent and RNA-independent mechanisms.

Human molecular genetics - 1 Oct 2014

Shelkovnikova Tatyana A, Robinson Hannah K, Southcombe Joshua A, Ninkina Natalia, Buchman Vladimir L

Abstract excerpt

Fused in sarcoma (FUS) is an RNA-binding protein involved in pathogenesis of several neurodegenerative diseases. Aggregation of mislocalized FUS into non-amyloid inclusions is believed to be pivotal in the development of cell dysfunction, but the mechanism of their formation is unclear. Using transient expression of a panel of deletion and chimeric FUS variants in various cultured cells, we demonstrated that FUS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasmic Granules

Share to Protein Aggregation, Pathological

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Source

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Identifiers

PMID: 24842888
DOI: 10.1093/hmg/ddu243
PMCID: PMC4159159

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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