Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The dimorphism of the multinucleated giant cells of gliomas.

Ultrastructural pathology - 1 Jan 2025

Barazi Muhi Dean, Aboubechara John Paul, Sulman Muhammad, Maraqah Haitham H, Abu-Asab Mones S, Lee Han Sung, Aboud Orwa

Abstract excerpt

Extensive research has begun to uncover the molecular characteristics of high grade gliomas. However, an ultrastructural understanding of their pathogenesis remains largely unexplored. Multinucleated giant cells are large cells with multiple nuclei thought to form from the fusion of multiple neoplastic cells. In this study, we aim to elucidate the nature of the multinucleated giant cells (MGCs) within IDH1-wild...

Read the complete abstract on PubMed

Topics

Humans
Giant Cells
Brain Neoplasms
Female
Male
Middle Aged
Glioma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Microscopy, Electron, Transmission

Adult

Aged

Glioblastoma

Astrocytoma

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 40851283
DOI: 10.1080/01913123.2025.2551738
PMCID: PMC12456927

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The dimorphism of the multinucleated giant cells of gliomas.PMID 40851283Read ↗

Cytogenetic and Molecular Characterization of IDH-Wildtype Glioblastomas and Grade 4 IDH-Mutant Astrocytomas with Unusual Histology.Semantic proximity Read ↗

IDH-wild type glioblastomas featuring at least 30% giant cells are characterized by frequent RB1 and NF1 alterations and hypermutation.Semantic proximity Read ↗

Giant cell glioblastoma is a distinctive subtype of glioma characterized by vulnerability to DNA damage.Semantic proximity Read ↗

Polymorphous oligodendroglioma of Zülch revisited: a genetically heterogeneous group of anaplastic gliomas including tumors of bona fide oligodendroglial differentiation.Semantic proximity Read ↗

Hypoxia-induced polypoid giant cancer cells in glioma promote the transformation of tumor-associated macrophages to a tumor-supportive phenotype.Semantic proximity Read ↗

Astrocytoma and glioblastoma IDH1-wildtype cells colonize tumor vessels and deploy vascular mimicry.Semantic proximity Read ↗

Gemistocytes in newly diagnosed glioblastoma multiforme: Clinical significance and practical implications in the modern era.Semantic proximity Read ↗

Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitorsSemantic proximity Read ↗

The advanced development of Cx43 and GAP-43 mediated intercellular networking in IDH1 wildtype diffuse and anaplastic gliomas with lower mitotic rate.Semantic proximity Read ↗

Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma.Semantic proximity Read ↗

SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma.Semantic proximity Read ↗

Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.