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Senescence: A DNA damage response and its role in aging and Neurodegenerative Diseases

21 Mar 2024

Abstract excerpt

Senescence is a complicated, multi-factorial, irreversible cell cycle halt that has a tumor-suppressing effect in addition to being a significant factor in aging and neurological diseases. Damaged DNA, neuroinflammation, oxidative stress and disrupted proteostasis are a few of the factors that cause senescence. Senescence is triggered by DNA damage which initiates DNA damage response. The DNA damage response,...

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Share to Genetics, Aging, and Longevity in Model Organisms
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Identifiers

PMID: 38596783
DOI: 10.3389/fragi.2023.1292053

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