Article

Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple Myeloma

2025-04-15

Abstract excerpt

<title>Abstract</title> <p>We demonstrate that carcinogenesis and multi-therapy resistance in multiple myeloma (MM)—a treatable yet incurable plasma cell malignancy—are driven by epigenetic dysregulation. In this new paradigm, genomic and cytogenetic events unlock epigenetic plasticity, reshaping MM cell biology to evade tumor microenvironment constraints and therapeutic pressure. These conclusions are derived fr...

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Literature Corpus work: b8a222fc-f8a2-543d-abe6-29f01dd57bac
DOI: 10.21203/rs.3.rs-6306816/v1

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