Zika virus-induced fetal demise is triggered by strain- and dose-specific RLR-driven activation of the interferon response in the decidua, placenta, and fetus in Ifnar1 −/− mice

Abstract excerpt

ABSTRACT Congenital Zika syndrome (CZS), the set of fetal and neonatal complications associated with Zika virus (ZIKV) infection in pregnancy, was first noted during the outbreak in the Americas in 2015–2016. However, there was an unequal distribution of ZIKV cases and severe outcomes in all areas where ZIKV emerged in the Americas, demonstrating that the risk of CZS varied over space and time. Recently, we...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to COVID-19 Impact on Reproduction
• Share to interferon and immune responses
• Share to Mosquito-borne diseases and control