Animal models of congenital zika syndrome provide mechanistic insight into viral pathogenesis during pregnancy

Abstract excerpt

In utero Zika virus (ZIKV; family Flaviviridae) infection causes a distinct pattern of birth defects and disabilities in the developing fetus and neonate that has been termed congenital zika syndrome (CZS).Over 8,000 children were affected by the 2016 to 2017 ZIKV outbreak in the Americas, many of whom developed CZS as a result of in utero exposure.To date, there is no consensus about how ZIKV causes CZS; animal...

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