Article
An Immunocompetent Mouse Model of Zika Virus Infection.
Cell host & microbe - 9 May 2018
Gorman Matthew J, Caine Elizabeth A, Zaitsev Konstantin, Begley Matthew C, Weger-Lucarelli James, Uccellini Melissa B, Tripathi Shashank, Morrison Juliet, Yount Boyd L, Dinnon Kenneth H, Rückert Claudia, Young Michael C, Zhu Zhe, Robertson Shelly J, McNally Kristin L, Ye Jing, Cao Bin, Mysorekar Indira U, Ebel Gregory D, Baric Ralph S, Best Sonja M, Artyomov Maxim N, Garcia-Sastre Adolfo, Diamond Michael S
Abstract excerpt
Progress toward understanding Zika virus (ZIKV) pathogenesis is hindered by lack of immunocompetent small animal models, in part because ZIKV fails to effectively antagonize Stat2-dependent interferon (IFN) responses in mice. To address this limitation, we first passaged an African ZIKV strain (ZIKV-Dak-41525) through Rag1-/- mice to obtain a mouse-adapted virus (ZIKV-Dak-MA) that was more virulent than...
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