MGMG: Cell Morphology-Guided Molecule Generation for Drug Discovery

Abstract excerpt

<h4>Design: </h4> ing novel molecules with desired bioactivity remains a fundamental challenge in drug discovery. Most molecular design methods follow target-based drug discovery paradigms that rely on well-defined drug targets, thereby limiting their applicability to diseases lacking known targets or reference compounds. Here we introduce Morphology-Guided Molecule Generation (MGMG), a phenotypic drug discovery–o...

Topics

Open a Topic to create a Post that cites this publication.

• Algorithms
• Cell Line
• Computational Biology
• Drug Design
• Drug Discovery
• High-Throughput Screening Assays
• Phenotype
• Structure-Activity Relationship

Identifiers and source

Literature Corpus work

673e66aa-9929-52ce-9fbe-1b4e5210afd6

DOI

10.1101/2025.07.11.664424