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Germline Targeted Baboon Apolipoprotein L-1 Protects Mice Against African Trypanosomes

2025-09-23

Abstract excerpt

Certain primates are immune to infection by most African trypanosome parasites due to apolipoprotein L-1 (APOL1), a primate-specific ion channel-forming protein. To broaden our understanding of primate APOL1, we generated a panel of trypanosome-resistant murine models expressing various primate APOL1 proteins. We used these mice to investigate the role of APOL1 in trypanosome immunity in vivo by challenging them...

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Identifiers and source

Literature Corpus work
6731692f-3b10-50fc-9b83-b62a83400116
DOI
10.1101/2025.09.23.676901
Open publication

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Germline Targeted Baboon Apolipoprotein L-1 Protects Mice Against African TrypanosomesDOI 10.1101/2025.09.23.676901
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