Article
Evolution of the primate trypanolytic factor APOL1.
Proceedings of the National Academy of Sciences of the United States of America - 20 May 2014
Thomson Russell, Genovese Giulio, Canon Chelsea, Kovacsics Daniella, Higgins Matthew K, Carrington Mark, Winkler Cheryl A, Kopp Jeffrey, Rotimi Charles, Adeyemo Adebowale, Doumatey Ayo, Ayodo George, Alper Seth L, Pollak Martin R, Friedman David J, Raper Jayne
Abstract excerpt
ApolipoproteinL1 (APOL1) protects humans and some primates against several African trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African Americans have additional trypanolytic activity against Trypanosoma brucei rhodesiense, the cause of acute African sleeping sickness. We combined genetic, physiological, and biochemical studies to explore coevolution between the APOL1 gene and...
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