Article
APOL1 renal risk variants have contrasting resistance and susceptibility associations with African trypanosomiasis.
eLife - 24 May 2017
Cooper Anneli, Ilboudo Hamidou, Alibu V Pius, Ravel Sophie, Enyaru John, Weir William, Noyes Harry, Capewell Paul, Camara Mamadou, Milet Jacqueline, Jamonneau Vincent, Camara Oumou, Matovu Enock, Bucheton Bruno, MacLeod Annette
Abstract excerpt
Reduced susceptibility to infectious disease can increase the frequency of otherwise deleterious alleles. In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a recessive kidney disease risk, named G1 and G2, occur at high frequency. APOL1 is a trypanolytic protein that confers innate resistance to most African trypanosomes, but not Trypanosoma brucei rhodesiense or T.b. gambiense,...
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