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Article

APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease.

Trends in molecular medicine - 1 Aug 2018

Beckerman Pazit, Susztak Katalin

Abstract excerpt

Chronic kidney disease (CKD) affects millions of people and constitutes a major health and financial burden worldwide. People of African descent are at an increased risk of developing kidney disease, which is mostly explained by two variants in the Apolipoprotein L1 (APOL1) gene that are found only in people of west African origin. It is hypothesized that these variants were genetically selected due to the...

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Identifiers

PMID: 29886044
DOI: 10.1016/j.molmed.2018.05.008
PMCID: PMC6101980

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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