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Article

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.

PLoS neglected tropical diseases - 1 Aug 2016

Cooper Anneli, Capewell Paul, Clucas Caroline, Veitch Nicola, Weir William, Thomson Russell, Raper Jayne, MacLeod Annette

Abstract excerpt

Humans are protected against infection from most African trypanosomes by lipoprotein complexes present in serum that contain the trypanolytic pore-forming protein, Apolipoprotein L1 (APOL1). The human-infective trypanosomes, Trypanosoma brucei rhodesiense in East Africa and T. b. gambiense in West Africa have separately evolved mechanisms that allow them to resist APOL1-mediated lysis and cause human African...

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Source

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Identifiers

PMID: 27494254
DOI: 10.1371/journal.pntd.0004903
PMCID: PMC4975595

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.PMID 27494254Read ↗

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Trypanosoma brucei gambiense Group 1 Is Distinguished by a Unique Amino Acid Substitution in the HpHb Receptor Implicated in Human Serum ResistanceSemantic proximity Read ↗

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