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Article

Genome-wide reconstruction of complex structural variants using read clouds.

Nature methods - 1 Sept 2017

Spies Noah, Weng Ziming, Bishara Alex, McDaniel Jennifer, Catoe David, Zook Justin M, Salit Marc, West Robert B, Batzoglou Serafim, Sidow Arend

Abstract excerpt

In read cloud approaches, microfluidic partitioning of long genomic DNA fragments and barcoding of shorter fragments derived from these fragments retains long-range information in short sequencing reads. This combination of short reads with long-range information represents a powerful alternative to single-molecule long-read sequencing. We develop Genome-wide Reconstruction of Complex Structural Variants...

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Identifiers

PMID: 28714986
DOI: 10.1038/nmeth.4366
PMCID: PMC5578891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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