Article

Outlier expression of isoforms by targeted RNA sequencing as clinical markers of genomic variants in B lymphoblastic leukemia and other tumor types

2022-07-31

Abstract excerpt

Recognition of aberrant gene isoforms indicative of underlying DNA events can impact molecular classification and risk stratification of B lymphoblastic leukemia (B-ALL). Aberrant ERG isoforms have been proposed as markers of the favorable-risk DUX4 -rearranged ( DUX4 r) subtype while deletion-mediated IKZF1 isoforms are associated with adverse prognosis in non- DUX4 r B-ALL. The high-risk IKZF1 plus signature dep...

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Literature Corpus work: 2aa9f988-3942-5aab-968a-c44f3602a20a
DOI: 10.1101/2022.07.29.22278149

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