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Mitochondrial Small RNA Alterations Associated with Increased Lysosome Activity in an Alzheimer’s Disease Mouse Model Uncovered by PANDORA-seq

26 Mar 2025

Abstract excerpt

Emerging small non-coding RNAs (sncRNAs), including tRNA-derived small RNAs (tsRNAs) and rRNA-derived small RNAs (rsRNAs), are critical in various biological processes, such as neurological diseases. Traditional sncRNA-sequencing (seq) protocols often miss these sncRNAs due to their modifications, such as internal and terminal modifications, that can interfere with sequencing. We recently developed panoramic RNA...

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PMID: 40243634
DOI: 10.3390/ijms26073019

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