Article

Destabilization of neuromuscular junctions and deregulation of activity-dependent signalling pathways in Myotonic Dystrophy type I

2023-03-10

Abstract excerpt

<h4>ABSTRACT</h4> Myotonic Dystrophy type I (DM1) is the most common muscular dystrophy in adults. Previous reports have highlighted that neuromuscular junctions (NMJs) deteriorate in skeletal muscle from DM1 patients and mouse models thereof. However, the underlying pathomechanisms and their contribution to muscle dysfunction remain unknown. We compared changes in NMJs and activity-dependent signalling pathways...

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Literature Corpus work: 66f2f084-c0b4-53de-9643-38e887e9348c
DOI: 10.1101/2023.03.08.531688

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