Article

CtBP1 coordinates synaptic, metabolic and contractile changes induced by denervation in skeletal muscle

2025-04-03

Abstract excerpt

Nerve injury triggers dramatic atrophy of skeletal muscle, accompanied with synaptic and metabolic changes. Regulation of denervation-induced muscle fiber remodeling involves several factors governing genetic reprogramming and proteostasis changes. Here, we demonstrate that the transcriptional co-repressor CtBP1 coordinates synaptic and metabolic changes in muscle fibers upon denervation. CtBP1 was present both in...

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Literature Corpus work: 255777d6-5948-5b80-9f18-e1798b2876ed
DOI: 10.1101/2025.03.29.646097

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