Article

Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors

2018-10-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Emery-Dreifuss Muscular Dystrophy (EDMD) is a disease characterized by skeletal muscle wasting, major tendon contractures, and cardiac conduction defects. Mutations in the gene encoding emerin cause EDMD1. Our previous studies suggested emerin activation of Histone Deacetylase 3 (HDAC3) to reduce Histone 4-Lysine 5 (H4K5) acetylation (ac) is important for myogenic differen...

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Literature Corpus work: 9a370aa2-ea8b-565a-975b-51a0fcc92dec
DOI: 10.1101/437343

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