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Article

MBNL‐dependent impaired development within the neuromuscular system in myotonic dystrophy type 1

28 Dec 2022

Abstract excerpt

AIMS: Myotonic dystrophy type I (DM1) is one of the most frequent muscular dystrophies in adults. Although DM1 has long been considered mainly a muscle disorder, growing evidence suggests the involvement of peripheral nerves in the pathogenicity of DM1 raising the question of whether motoneurons (MNs) actively contribute to neuromuscular defects in DM1. METHODS: By using micropatterned 96-well plates as a...

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PMID: 36575942
DOI: 10.1111/nan.12876

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