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Article

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

15 Feb 2022

Abstract excerpt

BACKGROUND: Histone deacetylase 4 (HDAC4) is a stress-responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never been fully investigated. Duchenne muscular dystrophy (DMD) is a genetic, progressive, incurable disorder, characterized by muscle wasting, which can be treated with...

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PMID: 35170869
DOI: 10.1002/jcsm.12891

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