Article

SON-dependent nuclear speckle rehabilitation alleviates proteinopathies

2024-04-21

Abstract excerpt

Current treatments targeting individual protein quality control pathways have limited efficacy in alleviating proteinopathies, highlighting the prerequisite for a common druggable target capable of global proteostasis modulation. Building upon our prior research establishing nuclear speckles as pivotal membrane-less organelles for transcriptional control of proteostasis, we aim to alleviate proteinopathies through...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66f16b4e-a850-5686-a42b-1d3ba008d40d
DOI: 10.1101/2024.04.18.590103

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SON-dependent nuclear speckle rehabilitation alleviates proteinopathiesDOI 10.1101/2024.04.18.590103Read

Spatial proteomic mapping of human nuclear bodies reveals new functional insights into RNA regulationSemantic proximity Read

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis modelsSemantic proximity Read

Correlating Protein Aggregate Structure with Cellular Function in Differentiated Muscle Cells: Discriminating Pathogenic from Non-Pathogenic FormsSemantic proximity Read

Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK ProteinsSemantic proximity Read

Mutations in nucleoporins and their roles in human diseases: Integrating evidence on specific NUP functions.Semantic proximity Read

Nuclear bodies protect phase separated proteins from degradation in stressed proteomeSemantic proximity Read

SWING regions prime chromatin for nuclear speckle–mediated gene regulationSemantic proximity Read

Disease-linked mutations dysregulate neuronal condensate physical properties, composition, and RNA translationSemantic proximity Read

Tailoring the positive and negative solvatochromism for chalcone analogues to detect heterozygous protein co-aggregation.Semantic proximity Read

Arginine-Enriched Mixed-Charge Domains Provide Cohesion for Nuclear Speckle Condensation.Semantic proximity Read

CDK12 condensation in nuclear speckles confers sensitivity to cyclin K molecular glue degradersSemantic proximity Read

Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunitSemantic proximity Read