Article

Nuclear Speckle Dynamics are Controlled by Polyphosphate Inhibition of CLK Proteins

2025-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Nuclear speckles (NS) are membrane-less nuclear organelles that act as critical hubs for pre-mRNA splicing. Defects in splicing are linked to several human diseases, including cancer, Alzheimer’s disease, and dystrophies. While CLK kinases regulate the mobilization of splicing factors from NS, the molecular mechanisms underlying NS assembly and dissolution remain unclear. Using an adaptation of...

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Literature Corpus work: 526c1707-fc86-577b-a28f-28b2361704a0
DOI: 10.1101/2025.01.15.633116

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