Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.

doi:10.1158/1078-0432.CCR-14-3049

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Article

Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2015

Hirbe Angela C, Dahiya Sonika, Miller Christopher A, Li Tiandao, Fulton Robert S, Zhang Xiaochun, McDonald Sandra, DeSchryver Katherine, Duncavage Eric J, Walrath Jessica, Reilly Karlyne M, Abel Haley J, Pekmezci Melike, Perry Arie, Ley Timothy J, Gutmann David H

Abstract excerpt

PURPOSE: Malignant peripheral nerve sheath tumors (MPNST) occur at increased frequency in individuals with neurofibromatosis type 1 (NF1), where they likely arise from benign plexiform neurofibroma precursors. While previous studies have used a variety of discovery approaches to discover genes associated with MPNST pathogenesis, it is currently unclear what molecular events are associated with the evolution of...

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PMID: 25925892
DOI: 10.1158/1078-0432.CCR-14-3049
PMCID: PMC4573781

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