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New models for MPNST: establishment and comprehensive characterization of two tumor cell lines

18 Jul 2025

Abstract excerpt

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are rare, invasive, and aggressive soft tissue sarcomas arising from peripheral nerves. They may occur sporadically or in association with Neurofibromatosis type 1 (NF1), in which they are the leading cause of mortality. Currently, there are no effective therapies other than surgery. Therefore, tumor-derived cell lines are essential for testing new...

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PMID: 40682039
DOI: 10.1186/s12935-025-03845-4

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