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Article

The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation.

Scientific reports - 8 Nov 2017

Brohl Andrew S, Kahen Elliot, Yoder Sean J, Teer Jamie K, Reed Damon R

Abstract excerpt

Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft tissue sarcoma. To more fully characterize the genomic landscape of this tumor type, we performed next generation sequencing studies for mutational and copy number analysis. We analyzed whole exome sequencing data from 12 MPNST and SNP arrays for a subset of these. We additionally conducted a literature review of prior next generation...

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Identifiers

PMID: 29118384
DOI: 10.1038/s41598-017-15183-1
PMCID: PMC5678116

Genes

EED
SUZ12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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